Searchable abstracts of presentations at key conferences in endocrinology

ea0020p458 | Obesity and Metabolism | ECE2009

Changes in serum levels of fetal antigen 1 (FA1/Pref-1/Dlk1) in extreme nutritional states

Andries Alin , Stoving Rene , Wolf Andrea , Beisiegel U , Horder Kirsten , Martin SB , Abdallah BM , Kassem Moustapha

Background: Also known as preadipocyte factor 1 (pref-1) or delta-like 1 (Dlk1), fetal antigen 1 (FA1) was originally isolated from amniotic fluid and it is involved in tissue homeostatis during development and tissue regeneration in the post-natal organisms. FA1 may also plays a role in energy metabolism since mice deficient in FA1 are obese and mice overexpressing FA1 exhibit a lipodystrophy phenotype.In our study we determined FA1 serum levels in pati...